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fhuC [2018-04-24 15:21:13]
hydroxamate siderophore [SW|ABC transporter ](ATP-binding protein) (ferrichrome und ferrioxamine)
function
siderophore uptake
product
hydroxamate siderophore [SW|ABC transporter ](ATP-binding protein) (ferrichrome und ferrioxamine)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.5|Uptake of iron/ siderophores][category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.1|ABC transporters for the uptake of iron/ siderophores][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.4|ABC transporters for the uptake of iron/ siderophores][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
3,415,387 → 3,416,196
The protein
Catalyzed reaction/ biological activity
ATP + H2O + iron chelate(Out) = ADP + phosphate + iron chelate(In) (according to Swiss-Prot)Structure
[PDB|4R9U], the ''E. coli'' BtuC-BtuD complex, BtuD shares 34% identity, 55% similarity with FhuC, [Pubmed|25402482][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|3E1C925C31C00803982C8EB1C6B025C22DB4A828|fhuB]-[gene|EC98685EE0E3CE6CE8DC33409481AE96315279AC|fhuG]-[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]
description
[pubmed|22383849]regulatory mechanism
[protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]: repression, [pubmed|12354229], in [regulon|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur regulon]regulation
induced by iron starvation (second wave to allow iron scavenging from the environment) ([protein|F899F1EE27E6D503BCC06BC52E3C7FD80B8EF725|Fur]) [pubmed|29133393,12354229]view in new tabBiological materials
Mutant
BKE33290 (Δ[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCGGCCCCCTCCTCT, downstream forward: _UP4_TGAAAAAATCCCGGTTTGAABKK33290 (Δ[gene|E70BE74D5AB4B06CDFF902E58A0B9EBF477E21EC|fhuC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTCGGCCCCCTCCTCT, downstream forward: _UP4_TGAAAAAATCCCGGTTTGAAReferences
10092453,16672620,25402482,12354229,29133393